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Trials

Title of trial Journal Ref. Intervention PRECIS-2 wheels
  Cimetidine in patients with gastric ulcer: a multi-centre controlled trial Frost F et al. Drug - cimetidine 1g/day
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  Reducing hospital admission through computer supported education for asthma patients. Grampian Asthma Study of Integrated Care (GRASSIC) Osman LM et al. Behavioural change (patients) - four printed booklets on asthma management covering both regular control and action in acute episodes
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  Nicardipine versus nitroprusside for breakthrough hypertension following carotid endarterectomy Dorman T et al. Drug - administration of nicardipine or nitroprusside
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  The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients Aronson S et al. Drug - IV clevidipine
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  Postoperative hypertension: a multicenter, prospective, randomized comparison between intravenous nicardipine and sodium nitroprusside Halpern NA et al. Drug - administration of iv nicardipine or sodium nitroprusside
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  Achieving lipid goals in real life: the Dutch DISCOVERY study Bots AFE et al. Drug - 12 week treatment with Rosuvastatin 10mg
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  Comparison of effects on low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with rosuvastatin versus atorvastatin in patients with type IIa or IIb hypercholesterolemia Davidson M et al. Drug - 12 week treatment with Rosuvastatin 10mg
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  Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil Bogani P et al. Drug - 50mg Extra virgin olive oil together with 150g of potatoes
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  The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial Covas MI et al. Drug - Extra Virgin Olive Oil (high phenolic content 366 mg/kg) for 3 weeks with 2 week wash out period
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  A prospective randomized comparison between paclitaxel and sirolimus stents in the real world of interventional cardiology: the TAXi trial Goy J-J et al. Drug - Sirolimus and Paclitaxel Stents for Percutaneous Coronary Intervention (PCA)
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  A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization Morice MC et al. Drug - Sirolimus-eluting stent
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  Incremental cost-effectiveness of drug-eluting stents compared with a third-generation bare-metal stent in a real-world setting: randomised Basel Stent Kosten Effektivitats Trial (BASKET). Kaiser C et al. Drug - third generation drug-eluting stents
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  TAXUS I: six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesions. Grube E et al. Drug - Slow-release Packlitaxel-eluting stent
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  Second-generation everolimus-eluting and paclitaxel-eluting stents in real-life practice (COMPARE): a randomised trial. Kedhi E et al. Drug - paclitaxel-eluting stents
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  Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial Brady AR et al. Drug - Beta blocker during surgery
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  The effects of perioperative beta-blockade: results of the Metoprolol after Vascular Surgery (MaVS) study, a randomized controlled trial. Yang H et al. Drug - Beta blocker Metropolol 50mg - perioperatively for vascular surgery
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  Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study) Jones P et al. Drug - Arvorvostatin, up to 80mg a day
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  Clinical outcomes in managed-care patients with coronary heart disease treated aggressively in lipid-lowering disease management clinics: the alliance study Koren MJ et al. Drug - Arorvastatin to maximum 80mg/day
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  Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection?--results of a randomized controlled pilot trial Bleidorn J et al. Health services delivery and reconfiguration - GPs use ibuprofen 3 x 400 mg oral in the treatment of uncomplicated urinary tract infection (UTI)
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  Long-term follow-up of participants with heart failure in the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT) Piller LB et al. Drug - amlodipine (2.5-10 mg/d), lisinopril (10-40mg/d), and chlorthalidone 12.5-25mg/d)
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  Coronary stent restenosis in patients treated with cilostazol Douglas JS et al. Drug - cilostazol 100 mg BID for 6 months
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  Comparison of zotarolimus-eluting and everolimus-eluting coronary stents Serruys PW et al. Drug - Second generation Zotarolimus-eluting resolute stents
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  A randomized controlled trial in second-generation zotarolimus-eluting Resolute stents versus everolimus-eluting Xience V stents in real-world patients: the TWENTE trial von Birgelen C et al. Drug - Zotarolumus-eluting Resolute stents
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  Multicenter randomized trial evaluating the efficacy of cilostazol on ischemic vascular complications after drug-eluting stent implantation for coronary heart disease: results of the CILON-T (influence of CILostazol-based triple antiplatelet therapy ON ischemic complication after drug-eluting stenT implantation) trial Suh J-W et al. Drug - Cilostazol (loading dose 200mg, then 100mg BD for 6 months)
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  ATTMH Abernethy JD et al. Drug - antihypertensive therapy
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  BARRACLOUGH Barraclough M et al. Drug - bendrofluazide with potassium supplement, methyldopa, or debrisoquine
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  HSCSG 1974 Effect of antihypertensive treatment on stroke recurrence. Hypertension-Stroke Cooperative Study Group. JAMA 1974 et al. Drug - anti-hyptertensive
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  Carter Carter AB et al. Drug - Anti-hypertensive treatment
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  Dutch Dutch et al. Drug - Anti-hyptertensive
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  EWPHB Amery A et al. Drug - Anti hypertensive
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  HOPE Yusuf S et al. Drug - anti-hypertension drug
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  HYVET Beckett NS et al. Drug - Anti-Hypertensive
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  MRC-O Medical Research Council trial of treatment of hypertension in older adults et al. Drug - Anti-hypertensive
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  MRC-TMH MRC trial of treatment of mild hypertension et al. Drug - anti-hypertensive
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  Oslo Helgeland A et al. Drug - Anti-hyptertensive
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  PATS Post-stroke antihypertensive treatment study. A preliminary result. Chin Med J (Engl) 1995 et al. Drug - anti-hypertensive
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  SHEP Rationale and design of a randomized clinical trial on prevention of stroke in isolated systolic hypertension. The Systolic Hypertension in the Elderly Program (SHEP) Cooperative Research Group. J Clin Epidemiol 1988 et al. Drug - Anti-hypertensive
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  SHEP pilot Perry HM et al. Drug - Anti-hypertensive
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  SYST-EUR Staessen JA et al. Drug - anti-hypertensives
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  USPHSHCSG Smith WM et al. Drug - Anti-hypertensives
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  TEST Eriksson S et al. Drug - Anti-hypertensive
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  UKPDS Perry HM et al. Drug - Anti-hypertensive
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  VA-1 Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA 1967 et al. Drug - Anti-hypertensives
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  VA-11 Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg. JAMA 1970 et al. Drug - Anti-hypertensives
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  Wolff Wolff FW et al. Drug - Anti-hypertensive
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  VA-NHLBI Evaluation of drug treatment in mild hypertension et al. Drug - Anti-hypertensives
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  HYVET pilot Bulpitt CJ et al. Drug - Anti-hypertensive
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  Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization Topol EJ et al. Drug - Tirofiban
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  COPERS, Effectiveness and cost-utility of a group self-management support intervention (COPERS) for people with chronic musculoskeletal pain: a randomised controlled trial Carnes D et al. Behavioural change (patients) - Self-management course
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  PALOMA - Drug - ALENDRONATE -vs- PLACEBO
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  GISSI Trial: EFFECTIVENESS OF INTRAVENOUS THROMBOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION GRUPPO ITALIANO PER LO STUDIO DELLA STREPTOCHINASI NELL’INFARTO MIOCARDICO (GISSI)* Lancet 1986 Feb 22;1(8478) et al. Drug - Intravenous thrombolytic treatment in acute myocardial infarction
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  The Maintaining Musculoskeletal Health (MAmMOTH) Study Macfarlane et al. Behavioural change (patients) - CBT
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  SPPA trial (A multicenter, assessor-blinded, controlled, randomised, parallel group, superiority, pragmatic trial assessing the effectiveness of daily SMS-reminders in Pharmaceutical Care of older adults with hypertension on improving Patients’ Adherence to blood pressure-lowering medication) HARAMIOVA et al. Behavioural change (patients) - SMS reminders of blood pressure-lowering medicines intake
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  Phase III Trial of Carboplatin and Paclitaxel Compared With Cisplatin and Paclitaxel in Patients With Optimally Resected Stage III Ovarian Cancer: A Gynecologic Oncology Group Study Ozols et al. Drug - Carboplatin (AUC 7.5mg/mL/min) + paclitaxel (175mg/m3) as a 3-hour infusion
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  The Bacteriuria in Renal Transplantation (BiRT) study: a prospective, randomized, parallel-group, multicenter, open-label, superiority trial comparing antibiotics versus no treatment in the prevention of symptomatic urinary tract infection in kidney transplant recipients with asymptomatic bacteriuria The BiRT study protocol has been published by The Lancet (http et al. Drug - Antibiotics (10 days): started according to the antibiogram results. The choice of antimicrobial agents is at the discretion of the physician.
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  E-ASSIST - Other - Offer of e-cigarette starter kit
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  Efficacy of an Active Geriatric Evaluation for Geriatric Syndromes to Prevent Functional Decline in Family - Health services delivery and reconfiguration - The AGE tool consists of a 20-minute clinical screening instrument (Brief Assessment Tool, BAT), which performances for identifying geriatric syndromes was already assessed in general practice along the AGE program, and a comprehensive approach that encompasses complementary diagnostic evaluations and propositions of management & treatment for each syndrome.
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